Author: Xu Lei
Bachelor of plant protection, Shandong Agricultural University. Master of insect ecology, Nanjing Agricultural University. He is currently working in the Ministry of foreign trade of Jiangsu agricultural and foreign trade, responsible for foreign trade, product knowledge training and operation of official account.
Flonicamid is a pyridylamide (or nicotinamide) insecticide discovered by Ishihara Industries Co., Ltd. of Japan. It can effectively prevent and control stinging mouthparts pests on a wide range of crops, especially aphids. Its mechanism of action is novel, it has no cross resistance with other insecticides on the market at present, and it is low toxic to honeybee. A number of companies participated in the development, including the United States of America, South Korea's eastern Hannong Co., Ltd., India United phosphatide, etc.
Flutamide began its formal efficacy test in 1998, and was listed in 2003. Its sales volume in 2009 was 35 million US dollars, with an average annual growth rate of 28.5% in 2004-2009. Shiyuan industry has set a global sales target for flutamide, with an annual sales volume of at least US $50 million. Flutamide market started in the United States, and then set foot in Europe, Asia and Latin America, etc. it has been registered and listed in more than 30 countries in the world.
Flutamide in bad time
Although flutamide and thiamethoxam were in the same month in China and Europe, the patent expired, but the sharp contrast with the popularity of thiamethoxam is that the market of flutamide is a lot of low-key because of the price disadvantage and poor quick availability.
New opportunities?
In recent years, flutamide has emerged on the other hand because of the cold of the new nicotine insecticides. Because of the new nicotine insecticides represented by thiametholine and thiamethoxam, they will seriously damage the ability of honeybees to navigate, search for food, reproduce and form new colonies. The European Union banned five new nicotine insecticides from outdoor use in April, and Canada recently decided to phase them out. The market vacancy of insecticides for piercing and sucking mouthparts gradually occupied by new products such as flutamide and flutaminil.
Fluridinylamide is the only member of the 9C group of selective homopteran antifeedant products. Its unique mechanism is highly effective for aphids, and it has no adverse effects on beneficial arthropods, such as Bombyx mori, Apis mellifera, Harmonia axyridis, Phytoseiulus persiulis and typodiromus Piri. It has no cross resistance with current mainstream insecticides and can be used for pest control with resistance to these insecticides and new nicotine insecticides.
About patent protection
PCT / European patent; compound patent (Japan Ishihara Industry Co., Ltd., pyridylamide and its salt, their production process and pesticide composition), ep0580374, valid until July 16, 2013; its European patent can not expire until July 2018 due to the British supplementary protection certificate (SPC).
Preparation patent (Ishihara Industries Co., Ltd., pyridylamide and its salt, their production process and pesticide composition), ep0580374, patent validity until July 16, 2013;
Other patents (dispersible pesticide compositions), wo2005104846, with patent protection period up to April 13, 2025.
US Patent: Compound patent (Japan Ishihara Industry Co., Ltd., amide compound and its salt, and their pesticide composition), us5360806, the patent protection period of which expires on July 23, 2013.
Chinese patent: compound and preparation patent (Shiyuan Industry Co., Ltd.; amide compound and its salt, their manufacturing process and pesticide composition), cn10816780, cn1044233, with patent application date of July 23, 1993 and patent protection period of July 22, 2013.
As a whole, the patent for the technical and synthetic preparation of fluridamide has expired, and domestic enterprises can legally produce and register overseas. However, some patents of preparations are still under protection, and their production still needs to pay attention to patent issues.
About registration
The compound patent application of flutamide in China was filed on July 23, 1993 and expired on July 22, 2013. March 24, 2017. Flutamide technical will go through the formal registration protection period, which is an opportunity for enterprises that want to apply for flutamide technical registration according to the technical products with no significant difference in quality beyond the formal registration protection period.
At present, there are 11 technical registration of fluridamide in China, among which the content of 7 registration is 96% of that of Shiyuan industry. Shandong Union has the highest content of registration: 98.5%. Wuxi Jiabao and Shaanxi Thompson are the new certificates obtained in 2018, except for Shiyuan industry, other certificates were obtained in 2017.
The registration of its preparation mainly includes wettable powder, water dispersible granule, suspending agent and suspending emulsion. It is mainly compounded with Isoprocarb, fludinylurea, spirodinyl ester and new nicotine insecticides. The main targets of registration were rice planthopper, vegetable and fruit aphid. In order to make up for the deficiency of flutamide's quick effect and give full play to its advantage, the mixture of flutamide and available components, such as pyrethroids or carbamates, can be used to promote flutamide products in pollinated crops.
Analysis of main competitive products
The competitive products of flutamide mainly come from two aspects;
One is the traditional new nicotine insecticide.
In the years when the outbreak of pests is not severe, low price and quick availability are the dominant factors in the market, and there is a great pressure on flutamide. However, with the attention paid to the potential harm of new nicotine insecticides to honeybees, flutamide, which is relatively safe to honeybees, will occupy a large market share. This phenomenon has been applied and marketed in pear fruits in Germany and France In terms of occupancy, it has been reflected (in the EU region, pear fruit planting areas are generally adjacent to bee farms). At the same time, with the expiration of flutamide patent, a large number of domestic imitation enterprises have emerged, lowering the overall price of flutamide preparation, instead, countries can use the prohibition and restriction of new nicotine products to seize the market of traditional new nicotine insecticides.
Second, new products of transnational corporations.
Chlorantranili prole of DuPont company has high inhalative activity, low dosage and rapid action. It has a strong advantage over flutamide in quick effect. However, in recent years, due to the extensive use of kangkuan, it has caused serious drug resistance. At present, in terms of rice insecticides, flutamide can account for a large proportion due to the resistance of chlorantranili According to one place.
Another product that is often compared with flutamide is flutaminil of Dow Yinong, which is still in the patent period. Compared with flutamide, it has no advantage in production and price.
As a whole, flutamide, as a unique insecticide product, has better action mode, safety and residue than the current new nicotine insecticides. If domestic imitation enterprises can control the cost in the promotion process, they can seize part of the current market dominated by new nicotine in major economic crop regions (fruits, vegetables, horticulture, etc.), such as Latin America , Asia Pacific region, etc.; at the same time, in the current market of flutamide single agent, domestic imitation enterprises can also promote the same single agent, more convenient to open the market.
Where is the way?
Due to the limited use of new nicotine products in Europe, we can foresee the high-end market in Europe in the future. Flutamide has great growth potential, especially for pollinated crops.
In the middle market of Asia Pacific and Southeast Asia, the problem of resistance to nicotine insecticides and kangkuan is becoming more and more serious. As a safe feeding inhibitor to natural enemies and honeybees, flutamide can occupy a certain rice insecticide market.
At present, the price difference of flutamide in each market area is relatively small, and it is basically close to the mainstream competitive products; for domestic raw drug manufacturers, the high-end market in Europe and the United States should take the export of raw drugs as the guide, and gradually develop the preparation compound products with higher profits. For the Southeast Asia and South America markets, due to the mature preparation products as the leading (50% WG), the domestic price advantage and supply advantage are used to promote fruits and cash crops.
summary
The problem of bee venom has pushed the new nicotine insecticides to the forefront of controversy. Although the future and fate of the new nicotine insecticides still need to be determined by sufficient research data, there are many countries and regions around the world that prohibit or restrict the use of new nicotine insecticides. In addition, the market has long-term and frequent use of this kind of insecticides, the resistance of stinging mouthparts pests to it is on the rise. However, flutamide is low toxic to honeybees and has no cross resistance with new nicotine insecticides, so it can make up for the market gap left by the ban and restriction of new nicotine insecticides.
Market is a touchstone. In addition to a mature market environment, product performance is the most important consideration. Flutamide has two conditions, and its market prospect is worth looking forward to.
Article source: World agrochemical network
The new insecticide "Lizuo", which is jointly developed by China Agricultural Lihua and Shiyuan Industry Co., Ltd., is a new type of insecticide with good fast antifeeding activity to aphids and pteridoptera pests. It mainly contains flutamide, an active component of pyridylamide. The new compound is the only one of the 29th class compounds evaluated by the International Action Committee on insecticide resistance. It has unique mechanism of action and excellent control effect on all kinds of aphids (including resistant aphids). After spraying, aphids stop sucking juice within 1 hour, and it is not harmful to crops. It has the characteristics of good internal absorption, good conduction, low dosage, high activity, quick availability, long period of validity, environmental friendliness (beneficial biological safety for bees, etc.).
In order to fully test the control effect of the product and master the use technology of the product, three years of experiments and demonstrations have been carried out in different crops, such as peach, apple, watermelon, pear, vegetable, strawberry, wheat, cotton, potato, grape, etc. The results show that the product has high activity, good control effect can be achieved at low dose, strong internal absorption and transmission in the plant, and has good internal absorption and transmission It also has no interaction resistance with other traditional insecticides.
The farmers who have used the manual work give a thumbs up to the magic control effect of the manual work. They all say: "the effect of the manual work is really good. It has quick effect and high safety. It can save time and money, save labor, save time and money, and do not hurt bees.".
Next, let's see how the farmers of Hengshui Shenzhou use the masterpiece on the peach trees evaluate the masterpiece:
Details of using force:
Investigation of population base before application: large population, red aphid and pink aphid, and leaf curling. See below:
After 6000 times and 8000 times of application, the control effect was three days: aphid died of discoloration, and rolled leaves began to stretch. See below:
There are a large number of live insects after treatment with imidacloprid, as shown in the figure below
Control effect after 9 days of 8000 times application: see the figure below
Control effect of imidacloprid plus methomyl for the second time of conventional medicine: see the figure below
Control effect of 6000 and 8000 times drugs for 23 days, as shown in the figure below
The control effect of imidacloprid plus chlorpyrifos is shown in the following figure
There are three kinds of aphids that damage peach trees, i.e. red aphid, pink aphid and rumen aphid. Red aphid and pink aphid are common, while rumen aphid is only in some areas. Aphid sucks the juice of peach young tissue, and the damaged peach leaves